Management of radiation-induced angiosarcoma of the breast with total mastectomy and superficial inferior epigastric artery flap reconstruction: a case report

Background: Radiation-induced angiosarcoma of the breast is a rare but serious long-term complication radiation, often from adjuvant therapy for previous cancer treatment. Early lesions typically appear benign and are misattributed to trauma, however disease rapidly progressive has high recurrence rate poor prognosis. Common imaging modalities such as mammography ultrasound not sensitive, though magnetic resonance may be more reliable. Once diagnosis confirmed via histopathologic evaluation core-needle or punch biopsy, surgical treatment should delayed. Reconstruction with free flap provides an advantage over other reconstructive techniques by allowing adequate coverage large defect left maximal resection previously-irradiated tissue ideal oncologic wound healing outcomes.